A couple of days ago someone else asked this question, see:
https://www.knowbrainer.com/forums/forum/messageview.cfm?catid=3&threadid=35285&enterthread=y
The basic answer is no, not the built-in Dragon® Mouse Grid command. I have written standalone commands which work great on up to 10 monitors of any mix of resolutions and scales. All three applications are free, public domain and open source and the links to them:
My offerings are available via this website - look at the "Third-Party" forum:
https://www.knowbrainer.com/forums/forum/categories.cfm?catid=25
Monitor Grid:
https://www.knowbrainer.com/forums/forum/messageview.cfm?catid=25&threadid=34720&enterthread=y
This puts up a grid on the specified monitor (handles up to 10 monitors).
Window Grid:
https://www.knowbrainer.com/forums/forum/messageview.cfm?catid=25&threadid=34692&enterthread=y
This puts up a grid on the Active Window (it does not matter what monitor it is on).
Screen Grid:
https://www.knowbrainer.com/forums/forum/messageview.cfm?catid=25&threadid=34643&enterthread=y
This puts up a grid on the entire screen (includes all monitors).
All three of these are extremely flexible: the user may specify a preferred number of rows and/or columns; the transparency is user-adjustable; the font which labels each grid cell is adjustable (font family, size and style); all are completely language localizable.
-------------------------
-Edgar
DPI 15.3, 64-bit Windows 10 Pro, OpenOffice & Office 365, Norton Security, Shure X2U XLR to USB mic adapter with Audio Technica DB135 vocal mic, Asus X299-Deluxe Prime, Intel Core i9-7940X (14 core, 4.3 GHz overclocked to 4.9 GHz), G.SKILL TridentZ Series 64GB (4 x 16GB) DDR4 3333 (PC4 26600) F4-3333C16Q-64GTZ, NVIDIA GIGABYTE GeForce GTX 1060 GV-N1060G1 GAMING-6GD REV 2.0 6GB graphics card with 3 1920x1080 monitors